Stem Cell Therapy
What are Stem Cells?
These are undifferentiated cells in our bodies that have the capacity to change into any healthy cell in our body. Meaning they can change into skin, bone, heart and muscle cells to name a few. They have the ability to replicate substantially as compared to normal somatic cells such as skin. Stem cells are located throughout our body in almost every organ and tissue such as bone marrow, fat, teeth, muscles, etc. However, as other cells in our body, stem cells also age as we do. That is why the ReGen® Series uses stem cells from umbilical cord which are young and healthy.
Other Stem Cell Sources
At Ortho Adaptive Wellness, we utilize stem cells that are derived exclusively from the umbilical cord after delivery of a baby, which is the safest and least-invasive method of extraction available. Umbilical cord stem cells are strictly screened and sold in standardized concentrations. Using stem cells may give patients a wide range of benefits via procedures that can be conducted in under half an hour.
Other methods include:
Most embryonic stem cells (human embryonic stem cells, or hESCs) are derived from embryos donated from fertility clinics that perform in vitro fertilization, or IVF, which are ready to be discarded.
Adult stem cells can be extracted from bone marrow by aspiration, typically from the superior iliac crest or the sternum. This process may be painful, though much research has been done to reduce any pain incurred by patients during extraction.
Adipose-derived stem cells come from a patient’s fat tissue, which is surgically extracted via liposuction under general anesthesia.
A LOOK BACK: THE HISTORY OF STEM CELLS
Stem cells have been around for over a century. In fact, the term stem cell was used as early as 1868 and in 1909, Alexander Maximow lectured at the Berlin Hematological Society on a theory that all blood cells come from the same ancestor cell…..a stem cell. In 1968, the first bone marrow transplant occurred which was successful due to stem cells in the bone marrow. In 1978, stem cells were discovered in human cord blood.
From here on, there were many new types of stem cells discovered and the world of regenerative medicine commenced to take shape and show much promise. Presently, stem cells have the capacity to replace bone, fat, cartilage, heart tissue, muscle, etc.
This shows much promise for many disease states. In fact, there are greater than 5000 clinical studies with stem cells found on the United States clinictrials.gov website. This demonstrates the progress and promise of stem cells.
Stem Cell Treatment Today
Today, doctors in a wide variety of clinical settings include stem cell therapies to treat a myriad of conditions. Typical treatments are simple, safe, do not require anesthesia, and take about the same time as a regular office visit. Stem cells are currently being used in a number of medical applications, including the treatment of:
- Rheumatoid arthritis, Crohn’s disease, lupus and other autoimmune disorders
- Parkinson’s, ALS, Alzheimer’s and other neurological diseases
- Types I and II diabetes
- Heart diseases
- Respiratory disorders
- Athletic injuries
- Chronic pain Spinal cord injuries and other orthopedic conditions
- Dermatological disorders
- Cosmetic/aesthetic issues treated by cosmetic dermatologists
Our Stem Cells
The product we use is from Umbilical Cord Donations. product contains mesenchymal stem cells (MSCs) and is rich in growth factors from umbilical cord blood. We obtain these tissues under informed consent and strict ethical protocols. The cord from where we extract our stem cells are from safe, reliable hospital sources via a non-invasive, simple, and painless procedure.
Here’s how it works:
- Participating hospitals invite screened mothers expecting normal, healthy births to donate the resulting umbilical cord tissues. These otherwise discarded tissues are an excellent source of high-quality stem cells and growth factors which may be used in regenerative medicine. At the time of birth, a specialized nurse enters the delivery room to carry out the extraction procedures. The umbilical cord tissue and blood is extracted and taken to our lab which follows cGMP and GTP procedures. From here our regenerative medicine product is made.
- All the tissues obtained are screened under FDA standards in order to assure the safest and highest quality product. Our regenerative medicine product is sold in standardized concentrations making it easy for physicians to deliver a dependable product.
- The partner lab which ships our regenerative medicine product to doctors and clinics worldwide.
benefit of umbilical cord derived stem cells
Umbilical-cord-derived regenerative medicine product contains MSCs that are both safe and non-invasive for donors, as well as a reliable source for physicians.
Umbilical cord stem cells also come from the youngest postnatal cells and do not rely upon embryonic tissue (the use of which brings up ethical issue for some doctors and patients). Bone Marrow MSCs are the same age of the donor at the time of extraction.
Medical Conditions Treated
Today, physicians are using stem cell therapies in the treatment of a wide variety of medical diseases/disorders and traumas. Presently, the use of stem cells is becoming common practice with orthopedics as it may help deter a knee replacement or surgical procedure and improve function of joints following injury. Practitioners today are also using stem cells within disciplines such as pain management, cardiology, rheumatology, and neurology.
Cartilage and Joint Function Improvement
In the area of joint injury and degeneration, mesenchymal (MSC) stem cells are being used to improve the function of joints. There are greater than 20 clinical studies or case studies in the peer reviewed scientific literature all demonstrating that stem cells may regenerate tissue, improve function, reduce pain and improve the quality of life for those suffering from orthopedic problems.
Treatment of Heart Disease
Therapies for victims of cardiovascular disease (coronary heart disease, hypertension, stroke and congestive heart failure) now include the use of stem cells. Scientists have been able to culture MSCs to differentiate into cells resembling cardiomyocytes, the tissues lost when cardiac tissues are deprived of oxygen. So stem cell treatment may actually rebuild and replace damaged heart muscle tissue. In addition, clinical studies in cardiovascular disease have shown promise. In a 2012 study on treatments for ischemic cardiomyopathy (ICM), patients who received stem cell therapy reported increased functional capacity and improved quality of life.
Stem cell therapies have shown to be highly successful in the treatment of bone fractures. One review reports injections of stem cells achieving 75% union over 14 weeks in one case, and 88% union over four months in another in patients with non-union bone fractures.
Treatment of Autoimmune Disorders
Stem cell therapy could be an excellent, minimally-invasive treatment option for patients with lupus, rheumatoid arthritis, multiple sclerosis, and other autoimmune diseases. MSCs may help drive the patient’s immune system toward a more favorable TH1/TH2 balance, as well as increase the number of Treg cells. This has been clearly documented in clinical studies on over 100 patients with lupus and rheumatoid arthritis receiving umbilical cord MSCs.
The treatments aim to strategically remove problematic immune cells, and restore functional immune cells to the body. In one clinical trial of lupus patients, patients treated with MSCs experienced stable disease remission for 12 to 18 months. In another case, a patient with autoimmune inner ear disease was treated with MSCs and recovered normal hearing in one ear and moderate hearing in the other.
Treatment of Arthritis
Regenerative medicine therapies utilize the anti-inflammatory properties of mesenchymal stem cells to alleviate inflammation-related osteoarthritis (OA) pain. In a 2011 study, for example, patients with severe OA were injected with mesenchymal stem cells and found they were able to walk longer without pain and climb a greater number of stairs after treatment. A follow-up study five years later showed that improvements had decreased, but that the knee that had received stem cell treatment was still better than at baseline. There are many other studies similar to this all supporting the notion that stem cells may be beneficial in treating arthritic conditions.
Treatment of Parkinson’s Disease
Research is finding that stem cells found in bone marrow can be differentiated into cells to treat Parkinson’s disease. With Parkinson’s, the brain produces less and less dopamine over time, and the person loses the ability to control body movements. Recently, treatments using bone-marrow MSCs to differentiate into dopamine secretory cells have shown encouraging results: almost half of the patients in a Parkinson’s treatment study showed steady improvement over 10-36 months.
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